The chemical and topological structure of polymer networks can seldom be orthogonally controlled. For example, novel network topologies are often accessed via the direct incorporation of supramolecular assemblies into the network structure, introducing potentially undesirable chemical components. Here, we address this deficiency by programming topology into network precursors through the
Targeted drug delivery through the traceless release of Oct 17, 2016 Ni-catalyzed traceless, directed C3-selective C-H A highly efficient and general protocol for traceless, directed C3-selective C-H borylation of indoles with [Ni(IMes)2] as the catalyst is reported. Activation and borylation of N-H bonds by [Ni(IMes)2] is essential to install a Bpin moiety at the N-position as a traceless directing group, which enables the C3-selective borylation of C-H bonds. Traceless Cleavage of Protein–Biotin - Chemistry Europe Come undone: We demonstrate for the first time that it is possible to tracelessly regenerate biotin‐tagged biological amines (peptides and proteins) under extremely mild and biologically compatible conditions. These simple reagents offer new possibilities in the field of chemical biology, particularly in biorthogonal chemistry and proteomics. Leaving Groups as Traceless Topological Modifiers for the
A highly efficient and general protocol for traceless, directed C3-selective C-H borylation of indoles with [Ni(IMes)2] as the catalyst is reported. Activation and borylation of N-H bonds by [Ni(IMes)2] is essential to install a Bpin moiety at the N-position as a traceless directing group, which enables the C3-selective borylation of C-H bonds.
Minisci alkylation is of prime importance for its applicability in functionalizing diverse heteroarenes, which are core structures in many bioactive compounds. In alkyl radical generation processes, precious metal catalysts, high temperatures and excessive oxidants are generally involved, which lead to susta Most popular 2018-2019 organic chemistry articles Carboxylic Acids as A Traceless Activation Group for
Minisci alkylation is of prime importance for its applicability in functionalizing diverse heteroarenes, which are core structures in many bioactive compounds. In alkyl radical generation processes, precious metal catalysts, high temperatures and excessive oxidants are generally involved, which lead to susta Most popular 2018-2019 organic chemistry articles
Synthesis of hydroxyphthioceranic acid using a traceless Jul 27, 2014 Selenolysine: A New Tool for Traceless - Chemistry Europe